The Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) study is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL)-limiting diverticulitis. The COSMID trial focuses on both patient-reported outcomes and clinical outcomes that matter to patients. The results are expected to establish an evidence-based approach to the care of millions of patients per year in the United States and help people impacted by this common condition make more informed treatment decisions.The goal of the COSMID trial is to answer the question: For patients with QoL-limiting diverticulitis, is elective colectomy more effective than best medical management?
The study will aim to investigate and complete the following objectives :
- Compare patient-reported outcomes such as quality of life in patients with QoL-limiting diverticulitis randomized to elective colectomy vs. best medical management.
- Compare clinical outcomes such as number of subsequent episodes of diverticulitis between patients with QoL-limiting diverticulitis randomized to elective colectomy vs. best medical management.
- Compare healthcare utilization between patients with QoL-limiting diverticulitis randomized to elective colectomy vs. best medical management
