CODA Trial

The Comparison of the Outcomes of antibiotic Drugs and Appendectomy, or CODA, Trial was the largest study to date comparing appendectomy and antibiotics for appendicitis, with 1,552 participants enrolled from 25 sites in 14 states. Funded by the Patient-Centered Outcome Research Institute and designed in partnership with patient stakeholders, the CODA Trial aimed to answer the question, “Based on my unique characteristics, preferences, and outcomes of interest, are antibiotics as good as appendectomy?”